Description
Product Characteristics:
The organic anion transporter family of proteins mediate hepatic uptake of cardiac glycosides. OATP-D is a 710 amino acid member of the organic anion transporter protein family. As a multi-pass membrane protein, OATP-D mediates the Na+-independent transport of vasopressin, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II and other organic anions, but not estrone-3-sulfate, DPDPE, taurocholate, DHEAS or digoxin. OATP-D is ubiquitously expressed with highest levels present in leukocytes and spleen. OATP-D is expressed as four isoforms produced by alternative splicing events.
Subcellular location: Cell membrane
Synonyms: OATP D, OATP RP3, OATP3A1, OATPD, OATPRP3, Organic anion transporter polypeptide related protein 3, Organic anion transporting polypeptide D, PGE1 transporter, SLC21A11, Sodium independent organic anion transporter D, Solute carrier family 21 organic anion transporter member 11, Solute carrier family 21 member 11, Solute carrier organic anion transporter family member 3A1, FLJ40478, SO3A1_HUMAN.
Target Information: transports several types of prostaglandins\, may play a role in prostaglandin transport in vascular, renal, and reproductive systems [RGD, Feb 2006]